Endoscopic Total Corpus Callosotomy and Pan Commissurotomy is a cutting-edge, minimally invasive surgical technique pioneered by Dr. Ramesh Doddamani at AIIMS, New Delhi, for the management of severe, drug-resistant Lennox-Gastaut syndrome (LGS). LGS is a challenging epilepsy syndrome characterized by multiple seizure types, cognitive impairment, and poor response to medications. In such patients, surgical interventions aimed at disrupting seizure propagation can significantly improve quality of life.

This procedure employs endoscopic visualization to perform a complete disconnection of the corpus callosum along with additional commissural fibers (pan commissurotomy), thereby preventing the spread of epileptic activity between the cerebral hemispheres. By leveraging endoscopic guidance, the surgery requires smaller craniotomies and minimal cortical exposure, reducing operative trauma, blood loss, and risk of complications compared to traditional open callosotomy. The minimally invasive nature also allows for faster postoperative recovery and improved cosmetic outcomes.

Clinical experience with this approach has demonstrated significant reduction in drop attacks and overall seizure burden, highlighting its efficacy in carefully selected patients with LGS. The technique exemplifies Dr. Doddamani’s focus on precision-based, functional neurosurgery and his commitment to advancing minimally invasive options for complex epilepsy cases. By combining technological innovation with meticulous surgical planning, endoscopic total corpus callosotomy and pan commissurotomy represents a major step forward in the treatment of refractory pediatric and adult epilepsies.