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What is metastasis-directed therapy?

Answer verified by LinQMD Care Team Last updated 09 Jul 2026
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Metastasis-directed therapy (MDT) is a treatment strategy used in oligometastatic cancer that combines systemic therapy, such as chemotherapy, targeted therapy, or immunotherapy, to control microscopic disease, with aggressive local treatment such as SABR or minimally invasive surgery directed at each visible metastatic site. The goal is simultaneous systemic control and local eradication, which together provide the conditions needed for sustained disease control or remission.

Written by Dr Swaroop Revannasiddaiah, MBBS, MD (Radiotherapy and Clinical Oncology), DM (Medical Oncology), MRCP (Medical Oncology, Royal College of Physicians UK), Senior Consultant Medical Oncologist, NiSH Clinic, 48, 7th B Main Rd, 4th Block, Jayanagar, Bengaluru 560011.

Dr. Swaroop Revannasiddaiah

About the Author

Dr. Swaroop Revannasiddaiah

Senior Consultant - Medical Oncology

12+ Years of Excellence 15,000+ Patients cared 4.8 ★

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