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Dr. Ann Agnes Mathew

Dr. Ann Agnes Mathew

Consultant Paediatric Neurologist & Neuromuscular Specialist

MBBS, MRCPCH, FRCPCH, Fellow in Paediatric Neurology, Fellow in Paediatric Stroke, Fellow in Paediatric Epilepsy, Fellow in Paediatric Neuromuscular Disorders

15+ years Experience

15+ years Experience

Synapse Neuro Center
Virgo Health Care
SPARSH Hospital, Hennur

About Dr. Ann Agnes Mathew

Dr. Ann Agnes, completed MBBS as the best outgoing student from St. John’s Medical College. Her Paediatrics and Neonatal training were from Scotland with further training in Paediatric Neurology at Great Ormond Street Hospital, London, leading to specialization in Paediatric epilepsy, childhood stroke and Paediatric neuromuscular disorders from the Dubowitz Neuromuscular Centre. In 2018, she established the country's first Paediatric Neuromuscular Service, pioneering in novel therapies in Spinal Muscular Atrophy, including gene therapy. Being the country’s lead for the BPNA-led, Paediatric Epilepsy Training Courses, she is a keen educator who drives advancements in the field while ensuring world-class care for children.


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Dr. Ann Agnes is a leading Pediatric Neurologist specializing in child neurology, epilepsy in children, neuromuscular disorders and rare neurological conditions. She completed her Paediatrics and Neonatal training at Scotland, followed by Pediatric Neurology from Great Ormond Street Hospital, London. In 2018, she established India’s first Pediatric Neuromuscular Service, pioneering in the treatment of Spinal Muscular Atrophy. She manages complex epilepsy along with complementary treatments such as ketogenic diet therapy, Vagal Nerve Stimulation and epilepsy surgery evaluations. She continues to lead clinical trials, epilepsy training programs and fellowships, while mentoring specialists across India and beyond.


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Dr. Ann Agnes Mathew's Areas of expertise

  • Child Neurology & Developmental Conditions
  • Childhood Epilepsy 
  • Muscular Dystrophies 
  • Duchenne Muscular Dystrophy 
  • Spinal Muscular Atrophy 
  • Congenital Myopathies 
  • Myasthenia 
  • Childhood Stroke 
  • Cerebral palsy 
  • Neurodegenerative conditions 
  • Complex Epilepsy and its management including Ketogenic Diet, Epilepsy surgery evaluation and Vagal Nerve Stimulation 
  • Childhood Headaches
  • Social Communication Disorders such as Autism, Hyperactivity, Intellectual Daisability and Neurogenetic Conditions

Merits And Academic Awards: 

  • Awarded the best presentation at the 2024 World Muscle Society Congress in Prague on Proposal to Bridge the gap in rare neuromuscular conditions in resource limited settings and LMIC.
  • Awarded the best presentation on long term home non-invasive ventilation at INSPIRED conference in June2024 in Portugal.
  • Awarded the best presentation at the International Paediatric NIV meet in Barcelona, 2024 for home ventilation in LMIC.
  • Awarded the best platform presentation at the 2023 AOCN National Child Neurology conference in Pune for an algorithm on managing sleep hypoventilation in LMIC.
  • Was awarded the Times Health Care excellence award for the year 2019 for our work in Paediatric Neuromuscular disorders.
  • Won the best poster prize for “Predictors of HUS in E coli 0157 infection” at the Welsh Paediatric Society autumn meet in Nov 2006. (Dr. Joishy, Dr. A. A. Mathew, Dr. Palakurthy, Dr. Rangarajan.)
  • Was awarded “The Catholic Medical Guild of St. Luke, Bombay Award” for securing the highest marks in final MBBS in St. John’s Medical College, India in 2001.
  • Obtained Merit in Biochemistry, Anatomy, Physiology, Pathology and Ophthalmology.
  • Obtained Distinction in Pharmacology and Microbiology.
  • Secured the 19th rank in Karnataka, India at the 2nd year Pre-University exams in 1995. 
      

 Clinical Research: 

  • From Oct 2022: Sarepta sponsored study for DMD- Ongoing- Principal Investigator 

 Research And Audit: 

  • Clinical profile of children with suspected SDB & their PSG findings at a tertiary care centre in Bengaluru, India: Journal of Paediatric Pulmonology; Apri 2023
  • SMA Phenotype- genotype correlation – In press with DMCN- April 2023.
  • Cardiomyopathy in Duchenne Muscular Dystrophy: As single centre experience: JACC ASIA- April’22.
  • Sporadic hemiplegic Migraine with CACNA1A- Mutation masquerading as meningoencephalitis: Annals of Indian Academy of Neurology-Oct 2021.
  • SEPN1 related myopathy- The importance of diagnosis and challenges to management of CMD in resource poor settings: Annals of Indian Academy of neurology: July 2020
  • Clinical research: Actively recruited patients for ICISS trial in London 2010.
  • Was an observer for the original Sarepta and PTC trials for DMD for exon skipping and ATALUREN.
  • Feb 2021: Our series on DMD and cardiomyopathy was presented as a poster at the Neuromuscular genetics conference in Hyderabad. Mutations: diagnostic difficulties due to associated peripheral neuropathy.
  • Sep 2018: Lowe syndrome: Genetics helps in managing complications. JICNA and poster presentation with ICNC 2018.
  • Aug 2014, Neuromuscular Disorders, 24 (8): 677-83, Limb Girdle Muscular Dystrophy due to LAMA2
  • Nov 2013, Brain: Treatable childhood Neuronopathy caused by mutations in Riboflavin transporter RFVT2.
  • JULY 2012: Retrospective Audit on anaesthetic safety and diagnostic yield of needle muscle biopsy over a 4-year period in neuromuscular patients undergoing muscle biopsy under GA.
  • Case series on partial merosin deficient congenital muscular dystrophy - awaiting publication.
  • JAN 2011: Variation in muscle MRI findings in a family with MYH7 gene mutation presented at the BPNA conference.
  • FEB 2010: Prospective audit over 2 months on the utilisation of the General Neurology Clinic referral system at Great Ormond Street Hospital.
  • NOV 2006: Predictors for the development of HUS in E coli 0157 infection (Dr. Joishy, Dr. Mathew, Dr. Palakurthi, Dr. Rangarajan) – Won the best poster prize at the Welsh Paediatric Society Autumn Meet was presented at the
  • Paediatric Research Society meet on 21st September 2006 at Staffordshire.    
  • AUG 1999: Commonest clinical features in Down syndrome in different age groups in a South Indian population. 
      

National & International Presentations: 

  • Oct’24: World Muscle Conference, Prague, Czech Republic- Single disease MDT clinics to bridge the gap in LMIC.
  • Oct’23: World Muscle Conference, Charleston, USA
  • Mar’23: AOCN National conference: Workshop on MDT in Neuromuscular Disorders
  • Oct’22: World Muscle Conference, Canada
  • Sep’22: Faculty at the National Neuropedicon, Srinagar, India.
  • Mar’22: AOCN National conference: SOC in SMA and Neuromuscular Disorders
  • June 2021: AOCN webinar Series: DMD and UPDATES.
  • Feb’21: AOCN: Costly therapies in NMD
  • Oct’19, 2017 and 2016: Invited lectures at the national Neuropedicon and state Pedicon.
  • MAY 2012 / MAY 2010 / NOV 2009: Case presentations at Muscle Interest Group Meetings.
  • MAR 2012: Neuromuscular session at the yearly Practical neurology course, Institute of Child health, London.
  • OCT 2011/MAY 2011: Case presentations at Stroke Interest Group Meetings.
  • JULY 2011: Overview of neuromuscular presentations in infancy, at ICAN (Indian Child & Adolescent neurology Conference), Chennai.
  • JAN 2011: Poster presentation on MYH7 myopathy at the British Paediatric Neurology Association meeting in Edinburgh.
  • MAY 2010: Neuromuscular Update course held at the National Institute for Neurology and Neurosurgery. 

 

 

primary muscle disease awarddisease modefying therapies in spinal muscular

 

primary muscele diseaces

 

 

 

MBBS - St. John’s Medical College, Bangalore, 2000 with the Best Outgoing Student Award 

MRCPCH, Royal College for Paediatrics and Child Health, UK in 2007    

FRCPCH, Royal College for Paediatrics and Child Health, UK in 2021 

Fellowship in Paediatric Neurology, Great Ormond Street Hospital for Sick children, London, 2009 

Fellowship in Paediatric Epilepsy, Evelina Children's Hospital and Kings Health Partners, London, 2010 

Fellowship in Paediatric Stroke, Great Ormond Street Hospital for Sick children, London, 2011 

Fellowship in Paediatric Neuromuscular Disorders, Dubowitz Neuromuscular Centre, Great Ormond Street Hospital, London 2012 

Book Appointment

771, 10th Main Road, 34th Cross Rd, 4th Block, Jayanagar, Bengaluru, Karnataka 560011

Clinic Hours:
  • Mon | Wed | Fri
  • 10:00 AM - 04:00 PM

809, Tower B, Brigade Signature Towers, Kattamanallur Cross, Bangalore

Clinic Hours:
  • Saturday
  • 10:00am to 04:00pm
Contact:

Phone: 96551 33279

DivyaSree Avance, Hennur Bagalur Main Rd, Chikkanna Layout, HBR Layout, Geddalahalli, Bengaluru, Karnataka 560043

Clinic Hours:
Contact:






Conditions and Treatments

expertise
Child Neurology & Developmental Conditions

Dr. Ann Agnes Mathew specializes in child neurology, diagnosing and managing conditions affecting brain, spinal cord, and nerves in children. From developmental delays to neurological disorders, she provides expert care for conditions impacting movement, speech and cognition. Her patient-focused approach ensures timely interventions for better growth, learning and overall well-being.

expertise
Childhood Epilepsy

With years of experience in epilepsy management, Dr. Ann Agnes helps manage infants & young people with seizures that are complex and often involving treatment resistant epilepsy. She provides personalised care, including medication management, epilepsy surgery evaluation and dietary therapies like ketogenic diet. Her goal is always to improve the quality of life of a child while controlling seizures and addressing all the associated challenges and life style issues along with schooling and behavioural problems.

expertise
Muscular Dystrophies

Dr. Ann Agnes is an expert in diagnosing and managing muscular dystrophies, a group of genetic muscle disorders that cause weakness which is often progressive. She and her team have been part of providing the latest advanced therapies, including gene-based treatments and rehabilitation plans, to help children maintain mobility and independence. Her focus is on early diagnosis, multidisciplinary care, and improving long-term outcomes as well as quality of life.

expertise
Duchenne Muscular Dystrophy (DMD)

DMD is a severe, progressive muscle-wasting disorder that primarily affects boys. It leads to progressive muscle weakness, difficulty walking, and eventually impacts heart and lung function that is then life threatening. Early interventions, steroids, physical therapy, and advanced gene therapy options help slow progression and improve survival and outcomes. Research in exon-skipping and gene therapy along with standard of care, offers hope for improved treatment outcomes in managing this condition.

expertise
Spinal Muscular Atrophy (SMA)

SMA is a genetic disorder affecting the nerves that control muscle movement, leading to weakness, difficulty swallowing, and breathing issues. SMA is a progressive disease, but newer treatments like Nusinersen (Spinraza), Risdiplam, and Gene therapy (Zolgensma/Onasemnogene) have transformed the care of SMA, improving mobility and survival. Early diagnosis is key to better outcomes. This along with multidisciplinary care, ensures better outcomes and improved quality of life in these children and young people.

expertise
Myasthenia

Myasthenia in children can cause muscle weakness and fatigue, affecting mobility and daily activities. Dr. Ann Agnes Mathew offers expert diagnosis, medication management, and advanced therapies to help children with Myasthenia Gravis and congenital myasthenic syndromes regain strength and lead active lives.

expertise
Cerebral Palsy

Dr. Ann Agnes Mathew provides specialized care for cerebral palsy, helping children improve motor function, mobility, and independence. She offers multidisciplinary treatment plans, including physical therapy, medications, and advanced interventions, ensuring a better quality of life for children with cerebral palsy.

Dr. Ann Agnes Mathew's Expert Tips & Health Insights

Latest

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Articles by Dr. Ann Agnes Mathew

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By: Dr. Ann Agnes Mathew
21 April 2025

Rare Diseases in Children: Challenges, Advocacy and Hope

Most neurological diseases and conditions that affect small children and infants are rare. To give an example, children can have strokes, but they are not because of lifestyle choices, such as smoking or obesity as seen in the adult population.
Read More
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By: Dr. Ann Agnes Mathew
21 April 2025

Developmental Delays in Children: Early Signs and When to Seek Help

Children’s brain develops constantly, and the fastest pace of development is set between the first few years of life, more so during early infancy.
Read More
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By: Dr. Ann Agnes Mathew
21 April 2025

Epilepsy in Children Myths, Facts and Advances in Treatment

Epilepsy is a fairly common condition that is mostly treatable, affecting over 50 million people, the vast majority of whom are children. Hence obtaining a diagnosis as to what caused it and accessing the right treatment is of paramount importance as 70% are treatable.
Read More
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By: Dr. Ann Agnes Mathew
12 March 2025

Can brain surgery cure epilepsy

Epilepsy surgery or what is commonly called brain surgery, is one of the available modalities for treating epilepsy, where the area of the brain that causes seizures is removed.
Read More
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By: Dr. Ann Agnes Mathew
12 March 2025

Developmental Disorders: Should a child be held to a schedule

When one thinks about childhood, we often think of it as the golden age. While that is true, it is also the time of life when the human brain is most activeactive,
Read More
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By: Dr. Ann Agnes Mathew
11 March 2025

Why is it important to investigate Infantile or Epileptic Spasms (West syndrome)

Epileptic spasms during early childhood has devastating consequences. Its early identification through investigations such as EEG reduces neurodisability and changes the disease course due to early treatment.
Read More

Dr. Ann Agnes Mathew's Reviews

Dr. Ann Agnes Mathew's Reviews

Frequently Asked Questions

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Frequently Asked Questions

How can parents and caregivers help raise awareness about paediatric neurological disorders, according to Dr. Ann?

Dr. Ann encourages parents and caregivers to:

  • Educate and empower themselves on common paediatric neurological disorders
  • Join patient advocacy and support groups
  • Spread correct information to reduce stigma and myths
  • Engage with policymakers to advocate for better healthcare policies and funding

 

What support networks does Dr. Ann recommend for families of children with rare diseases?

Dr. Ann advises families to seek:

  • Patient support groups & NGOs- most of these are disease specific advocacy groups.
  • Clinical trials & research-based treatments
  • Government assistance programs for specific conditions
  • Medical crowdfunding & financial aid options

Dr. Ann actively works to build patient networks and raise awareness for rare diseases.

 

Can diet and lifestyle changes help manage epilepsy, and what does Dr. Ann recommend?

Dr. Ann strongly advocates dietary and lifestyle interventions for epilepsy, including:

  • A ketogenic diet (high fat, low carb), especially for drug-resistant epilepsy
  • Adequate sleep & stress management
  • Avoiding seizure triggers (flashing lights, dehydration, certain foods)
  • Strict medication adherence and regular doctor follow-ups
Does Dr. Ann recommend genetic testing for all neurological disorders?

Dr. Ann does not recommend genetic testing for all cases, but genetic testing is often crucial for certain conditions like epilepsy, muscular dystrophy, neurogenetic syndromes, and metabolic disorders. A specialist consultation is required to determine if genetic testing is necessary. Most children and infants are far more likely to have inherited conditions as opposed to the acquired or lifestyle disease seen in older adults.

What diagnostic tests does Dr. Ann use for paediatric neurological conditions?

Dr. Ann may recommend the following tests depending on the condition:

  • Neuro imaging: MRI or CT scans (to check brain structure)
  • EEG (Electroencephalogram) (to evaluate seizures and epilepsy) including Video EEG and long term EEG where mandated
  • Genetic testing (for conditions like Epilepsy, Neurodevelopmental disorders, muscular dystrophies, neurometabolic  and neurogenetic disorders)
  • Metabolic tests (for rare metabolic disorders)
  • Neurodevelopmental assessments (for autism, ADHD, learning disabilities)
When should parents consult Dr. Ann for concerns about speech delay in children?

Dr. Ann advises parents to seek medical advice if their child:

  • Does not babble by 9 months
  • Does not say single meaningful words by 12 months
  • Does not combine words using an ‘action word’ by 2 years
  • Struggles with social interaction, eye contact, or nonverbal communication

Early intervention with speech therapy backed by neurological evaluation leads to better outcomes and esnures opportunities for recovery are not missed.

How does Dr. Ann diagnose autism, and what steps should parents take after diagnosis?

Dr. Ann diagnoses autism using clinical observation, developmental history, and standardized assessment tests that aim to map the level of the child’s development and his or her deviation from what is expected age in other children their age. Steps after diagnosis include:

  1. Early intervention therapies (speech, occupational, behavioural therapy)
  2. Education & training for parents
  3. A multidisciplinary care plan, including support from Paediatric neurologists, early interventionists, speech therapists, psychologists, and allied therapists.

Ultimately what it does is uses, strenghths of the child to overcome their weaknesses, bearing in mind neuroplasticity timeline is not wasted.

What are the treatment options for muscular dystrophy that Dr. Ann offers?

Dr. Ann provides a multidisciplinary approach to treating muscular dystrophy all of which is tailor made dependent on the type of muscular dystrophy. These are all based on the current international standards of care in this group of conditions. They might include disease modifying therapies such as:

  • Steroid therapy to slow disease progression in Duchenne Muscular Dystrophy
  • Physical therapy & assistive devices for mobility but again tailor made, as it could be counterproductive otherwise.
  • Newer therapies such as Gene therapy & exon-skipping drugs (where applicable)
  • Comprehensive care involving pulmonology, cardiology, physiatrists, orthopaedic surgeons & endocrinologists
  • Participation in clinical trials and research-based treatments
Can epilepsy in children be cured, and what treatment options does Dr. Ann recommend?

Dr. Ann explains that about 70% of childhood epilepsy is treatable and can go into remission with medication. Some children may outgrow epilepsy, while others might need long-term management. For drug-resistant epilepsy, Dr. Ann might recommend ketogenic diet, Vagal nerve stimulation, or epilepsy surgery along with evaluation for their underlying cause.

What are the early signs of developmental delay that Dr. Ann advises parents to watch for?

Dr. Ann advises parents to look for early signs of developmental delay, including:

  • Delayed speech (not having any meaningful words by 12-months age, and not saying simple words by 18 months)
  • Delayed walking (The usual range is that an infant walks independently by 12 to 18 months, but what matters here more than the age of attainments, is the duration in months between standing with support and starting to walk, which should not exceed a few months)
  • Poor social interactions (not making eye contact, or responding to their name)
  • Difficulty with motor skills (grasping objects, sitting up, crawling)
  • Repetitive behaviours or lack of interest in surroundings

If these signs are present, Dr. Ann recommends early assessment and intervention.

What hospitals and medical centres is Dr. Ann affiliated with?

Dr. Ann is affiliated with multiple medical centres in Bangalore, India, including:

  • Synapse Neuro & Child Neuro and Developmental Centre, Jayanagar
  • Virgo Healthcare, Brigade Signature Towers, Katamnallur Cross
Does Dr. Ann offer teleconsultations for paediatric neurology cases?

Yes, Dr. Ann offers teleconsultations for follow-ups and second opinions. However, some conditions require in-person evaluations, especially for developmental assessments and neurological examinations. Tele consultations can be scheduled by contacting +91 99020 01412.

What inspired Dr. Ann to specialize in Paediatric neurology?

Dr. Ann has always been passionate about helping children with neurological disorders and making a difference in their lives. Her training in the UK and the high burden of paediatric neurological conditions in India inspired her to focus on this field. She is also actively involved in medical education, advocacy, and research

Where does Dr. Ann currently practice, and how can patients schedule an appointment?

Dr. Ann primarily practices in Bangalore, India. Patients can visit Dr. Ann’s at Synapse Neuro and Child development centre, Jayanagar by calling +91 99020 01412 or at Virgo Healthcare, Brigade Signature Towers, Old Madras Road by contact +91 99019 55252.

What is Dr. Ann’s specialization, and what conditions does Dr. Ann treat?

Dr. Ann is a paediatric neurologist who specializes in diagnosing and treating neurological disorders in children. Dr. Ann treats epilepsy both simple and complex, developmental delays, muscular dystrophies, cerebral palsy, neurogenetic disorders, autism-related neurological concerns and paediatric stroke.

What is Vagal nerve stimulation (VNS) and who can benefit?

VNS is a device that is implanted under the skin which helps people gain control of their epilepsy. It is particularly beneficial for anyone with poorly controlled epilepsy despite being on two or more medication. But this eligibility needs to be evaluated and recommended by an epilepsy specialist. 

Can cerebral palsy be treated or cured?

Cerebral palsy can be treated by early timely interventions that aim at using the neuroplasticity of young children’s brains. While it cannot be fully cured, we can certainly reduce its impact in the future life of the child. 

What is ketogenic diet and how does it help in epilepsy?

Ketogenic diet is an alternate treatment for epilepsy where the fuel for the brain is switched from glucose to ketones. This has been a proven way to treat epilepsy, especially drug-resistant epilepsy. 

Can children with cerebral palsy(CP) benefit from Dr. Ann’s expertise?

Yes, she provides personalized and holistic treatment plans, not limited to just epilepsy, tone and spasticity management but also dietetics, early intervention where applicable, including therapy guidance such as navigating life, education and society with CP. 

What are Dr. Ann Agnes Mathew’s areas of expertise?

Dr. Ann specializes in Paediatric Neurology, Childhood Epilepsy, Refractory and Complex epilepsy, Muscular Dystrophies, Spinal Muscular Atrophy (SMA), Paediatric Stroke, Cerebral Palsy, Myasthenias,  Headaches, Neurodevelopmental Disorders like Autism, ADHD and Intellectual disability. 

How can I consult Dr. Ann Agnes Mathew?

In person appointments can be booked through Synapse Neuro and Child Development Centre and Virgo Health Care. Online appointment can be booked through
 https://www.linqmd.com/doctor/ann-agnes

Can children with cerebral palsy benefit from Dr. Ann’s expertise?

Yes, she provides personalized treatment plans, including therapy guidance, spasticity management, and assistive technology support for children with Cerebral Palsy.
 

What role does Dr. Ann play in clinical research?

She is actively involved in clinical trials for neuromuscular disorders and has led research on epilepsy, genetic disorders, and rare paediatric neurological diseases.
 

How much experience does Dr. Ann Agnes Mathew have?

25 years as paediatrician and 15 years as paediatric neurologist 
 

What does Dr. Ann Agnes Mathew specialise in?

The primary specialization of Dr. Ann Agnes is Paediatric Neurology 
 

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Reach Dr. Ann Agnes Mathew

Synapse Neuro Center

771, 10th Main Road, 34th Cross Rd, 4th Block, Jayanagar, Bengaluru, Karnataka 560011 Ph no:+91 99020014121

Virgo Health Care

BRIGADE SIGNATURE TOWERS, Sannatammanahalli, Bengaluru, Karnataka 560049

SPARSH Hospital, Hennur

DivyaSree Avance, Hennur Bagalur Main Rd, Chikkanna Layout, HBR Layout, Geddalahalli, Bengaluru, Karnataka 560043