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Dr. Ann Agnes Mathew

Dr. Ann Agnes Mathew

Consultant Paediatric Neurologist & Neuromuscular Specialist

MBBS, MRCPCH, FRCPCH, Fellow in Paediatric Neurology, Fellow in Paediatric Stroke, Fellow in Paediatric Epilepsy, Fellow in Paediatric Neuromuscular Disorders

15+ years Experience

15+ years Experience

Synapse Neuro Center
Virgo Health Care
SPARSH Hospital, Hennur
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About Dr. Ann Agnes Mathew

Dr. Ann Agnes, completed MBBS as the best outgoing student from St. John’s Medical College. Her Paediatrics and Neonatal training were from Scotland with further training in Paediatric Neurology at Great Ormond Street Hospital, London, leading to specialization in Paediatric epilepsy, childhood stroke and Paediatric neuromuscular disorders from the Dubowitz Neuromuscular Centre. In 2018, she established the country's first Paediatric Neuromuscular Service, pioneering in novel therapies in Spinal Muscular Atrophy, including gene therapy. Being the country’s lead for the BPNA-led, Paediatric Epilepsy Training Courses, she is a keen educator who drives advancements in the field while ensuring world-class care for children.


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Dr. Ann Agnes is a leading Pediatric Neurologist specializing in child neurology, epilepsy in children, neuromuscular disorders and rare neurological conditions. She completed her Paediatrics and Neonatal training at Scotland, followed by Pediatric Neurology from Great Ormond Street Hospital, London. In 2018, she established India’s first Pediatric Neuromuscular Service, pioneering in the treatment of Spinal Muscular Atrophy. She manages complex epilepsy along with complementary treatments such as ketogenic diet therapy, Vagal Nerve Stimulation and epilepsy surgery evaluations. She continues to lead clinical trials, epilepsy training programs and fellowships, while mentoring specialists across India and beyond.


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Dr. Ann Agnes Mathew's Areas of expertise

  • Child Neurology & Developmental Conditions
  • Childhood Epilepsy 
  • Muscular Dystrophies 
  • Duchenne Muscular Dystrophy 
  • Spinal Muscular Atrophy 
  • Congenital Myopathies 
  • Myasthenia 
  • Childhood Stroke 
  • Cerebral palsy 
  • Neurodegenerative conditions 
  • Complex Epilepsy and its management including Ketogenic Diet, Epilepsy surgery evaluation and Vagal Nerve Stimulation 
  • Childhood Headaches
  • Social Communication Disorders such as Autism, Hyperactivity, Intellectual Daisability and Neurogenetic Conditions
Merits And Academic Awards: 
  • Awarded the best presentation at the 2024 World Muscle Society Congress in Prague on Proposal to Bridge the gap in rare neuromuscular conditions in resource limited settings and LMIC.
  • Awarded the best presentation on long term home non-invasive ventilation at INSPIRED conference in June2024 in Portugal.
  • Awarded the best presentation at the International Paediatric NIV meet in Barcelona, 2024 for home ventilation in LMIC.
  • Awarded the best platform presentation at the 2023 AOCN National Child Neurology conference in Pune for an algorithm on managing sleep hypoventilation in LMIC.
  • Was awarded the Times Health Care excellence award for the year 2019 for our work in Paediatric Neuromuscular disorders.
  • Won the best poster prize for “Predictors of HUS in E coli 0157 infection” at the Welsh Paediatric Society autumn meet in Nov 2006. (Dr. Joishy, Dr. A. A. Mathew, Dr. Palakurthy, Dr. Rangarajan.)
  • Was awarded “The Catholic Medical Guild of St. Luke, Bombay Award” for securing the highest marks in final MBBS in St. John’s Medical College, India in 2001.
  • Obtained Merit in Biochemistry, Anatomy, Physiology, Pathology and Ophthalmology.
  • Obtained Distinction in Pharmacology and Microbiology.
  • Secured the 19th rank in Karnataka, India at the 2nd year Pre-University exams in 1995. 
      
 Clinical Research: 
  • From Oct 2022: Sarepta sponsored study for DMD- Ongoing- Principal Investigator 
 Research And Audit: 
  • Clinical profile of children with suspected SDB & their PSG findings at a tertiary care centre in Bengaluru, India: Journal of Paediatric Pulmonology; Apri 2023
  • SMA Phenotype- genotype correlation – In press with DMCN- April 2023.
  • Cardiomyopathy in Duchenne Muscular Dystrophy: As single centre experience: JACC ASIA- April’22.
  • Sporadic hemiplegic Migraine with CACNA1A- Mutation masquerading as meningoencephalitis: Annals of Indian Academy of Neurology-Oct 2021.
  • SEPN1 related myopathy- The importance of diagnosis and challenges to management of CMD in resource poor settings: Annals of Indian Academy of neurology: July 2020
  • Clinical research: Actively recruited patients for ICISS trial in London 2010.
  • Was an observer for the original Sarepta and PTC trials for DMD for exon skipping and ATALUREN.
  • Feb 2021: Our series on DMD and cardiomyopathy was presented as a poster at the Neuromuscular genetics conference in Hyderabad. Mutations: diagnostic difficulties due to associated peripheral neuropathy.
  • Sep 2018: Lowe syndrome: Genetics helps in managing complications. JICNA and poster presentation with ICNC 2018.
  • Aug 2014, Neuromuscular Disorders, 24 (8): 677-83, Limb Girdle Muscular Dystrophy due to LAMA2
  • Nov 2013, Brain: Treatable childhood Neuronopathy caused by mutations in Riboflavin transporter RFVT2.
  • JULY 2012: Retrospective Audit on anaesthetic safety and diagnostic yield of needle muscle biopsy over a 4-year period in neuromuscular patients undergoing muscle biopsy under GA.
  • Case series on partial merosin deficient congenital muscular dystrophy - awaiting publication.
  • JAN 2011: Variation in muscle MRI findings in a family with MYH7 gene mutation presented at the BPNA conference.
  • FEB 2010: Prospective audit over 2 months on the utilisation of the General Neurology Clinic referral system at Great Ormond Street Hospital.
  • NOV 2006: Predictors for the development of HUS in E coli 0157 infection (Dr. Joishy, Dr. Mathew, Dr. Palakurthi, Dr. Rangarajan) – Won the best poster prize at the Welsh Paediatric Society Autumn Meet was presented at the
  • Paediatric Research Society meet on 21st September 2006 at Staffordshire.    
  • AUG 1999: Commonest clinical features in Down syndrome in different age groups in a South Indian population. 
      
National & International Presentations: 
  • Oct’24: World Muscle Conference, Prague, Czech Republic- Single disease MDT clinics to bridge the gap in LMIC.
  • Oct’23: World Muscle Conference, Charleston, USA
  • Mar’23: AOCN National conference: Workshop on MDT in Neuromuscular Disorders
  • Oct’22: World Muscle Conference, Canada
  • Sep’22: Faculty at the National Neuropedicon, Srinagar, India.
  • Mar’22: AOCN National conference: SOC in SMA and Neuromuscular Disorders
  • June 2021: AOCN webinar Series: DMD and UPDATES.
  • Feb’21: AOCN: Costly therapies in NMD
  • Oct’19, 2017 and 2016: Invited lectures at the national Neuropedicon and state Pedicon.
  • MAY 2012 / MAY 2010 / NOV 2009: Case presentations at Muscle Interest Group Meetings.
  • MAR 2012: Neuromuscular session at the yearly Practical neurology course, Institute of Child health, London.
  • OCT 2011/MAY 2011: Case presentations at Stroke Interest Group Meetings.
  • JULY 2011: Overview of neuromuscular presentations in infancy, at ICAN (Indian Child & Adolescent neurology Conference), Chennai.
  • JAN 2011: Poster presentation on MYH7 myopathy at the British Paediatric Neurology Association meeting in Edinburgh.
  • MAY 2010: Neuromuscular Update course held at the National Institute for Neurology and Neurosurgery. 

 

 

primary muscle disease awarddisease modefying therapies in spinal muscular

 

primary muscele diseaces

 

 

 

  • MBBS - St. John’s Medical College, Bangalore, 2000 with the Best Outgoing Student Award
  • MRCPCH, Royal College for Paediatrics and Child Health, UK in 2007    
  • FRCPCH, Royal College for Paediatrics and Child Health, UK in 2021
  • Fellowship in Paediatric Neurology, Great Ormond Street Hospital for Sick children, London, 2009
  • Fellowship in Paediatric Epilepsy, Evelina Children's Hospital and Kings Health Partners, London, 2010
  • Fellowship in Paediatric Stroke, Great Ormond Street Hospital for Sick children, London, 2011
  • Fellowship in Paediatric Neuromuscular Disorders, Dubowitz Neuromuscular Centre, Great Ormond Street Hospital, London 2012 

Book Appointment

Please select a clinic in the below dropdown to book your appointment

771, 10th Main Road, 34th Cross Rd, 4th Block, Jayanagar, Bengaluru, Karnataka 560011

Clinic Hours:
  • Mon | Wed | Fri
  • 10:00 AM - 04:00 PM

809, Tower B, Brigade Signature Towers, Kattamanallur Cross, Bangalore

Clinic Hours:
  • Saturday
  • 10:00am to 04:00pm
Contact:

Phone: 96551 33279

DivyaSree Avance, Hennur Bagalur Main Rd, Chikkanna Layout, HBR Layout, Geddalahalli, Bengaluru, Karnataka 560043

Clinic Hours:
  • Monday - Saturday
  • 09:00am to 03:00pm
Contact:

Conditions and Treatments

expertise
Child Neurology & Developmental Conditions

Dr. Ann Agnes Mathew specializes in child neurology, diagnosing and managing conditions affecting brain, spinal cord, and nerves in children. From developmental delays to neurological disorders, she provides expert care for conditions impacting movement, speech and cognition. Her patient-focused approach ensures timely interventions for better growth, learning and overall well-being.

expertise
Childhood Epilepsy

With years of experience in epilepsy management, Dr. Ann Agnes helps manage infants & young people with seizures that are complex and often involving treatment resistant epilepsy. She provides personalised care, including medication management, epilepsy surgery evaluation and dietary therapies like ketogenic diet. Her goal is always to improve the quality of life of a child while controlling seizures and addressing all the associated challenges and life style issues along with schooling and behavioural problems.

expertise
Muscular Dystrophies

Dr. Ann Agnes is an expert in diagnosing and managing muscular dystrophies, a group of genetic muscle disorders that cause weakness which is often progressive. She and her team have been part of providing the latest advanced therapies, including gene-based treatments and rehabilitation plans, to help children maintain mobility and independence. Her focus is on early diagnosis, multidisciplinary care, and improving long-term outcomes as well as quality of life.

expertise
Duchenne Muscular Dystrophy (DMD)

DMD is a severe, progressive muscle-wasting disorder that primarily affects boys. It leads to progressive muscle weakness, difficulty walking, and eventually impacts heart and lung function that is then life threatening. Early interventions, steroids, physical therapy, and advanced gene therapy options help slow progression and improve survival and outcomes. Research in exon-skipping and gene therapy along with standard of care, offers hope for improved treatment outcomes in managing this condition.

expertise
Spinal Muscular Atrophy (SMA)

SMA is a genetic disorder affecting the nerves that control muscle movement, leading to weakness, difficulty swallowing, and breathing issues. SMA is a progressive disease, but newer treatments like Nusinersen (Spinraza), Risdiplam, and Gene therapy (Zolgensma/Onasemnogene) have transformed the care of SMA, improving mobility and survival. Early diagnosis is key to better outcomes. This along with multidisciplinary care, ensures better outcomes and improved quality of life in these children and young people.

expertise
Myasthenia

Myasthenia in children can cause muscle weakness and fatigue, affecting mobility and daily activities. Dr. Ann Agnes Mathew offers expert diagnosis, medication management, and advanced therapies to help children with Myasthenia Gravis and congenital myasthenic syndromes regain strength and lead active lives.

expertise
Cerebral Palsy

Dr. Ann Agnes Mathew provides specialized care for cerebral palsy, helping children improve motor function, mobility, and independence. She offers multidisciplinary treatment plans, including physical therapy, medications, and advanced interventions, ensuring a better quality of life for children with cerebral palsy.

Dr. Ann Agnes Mathew's Expert Tips & Health Insights

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Articles by Dr. Ann Agnes Mathew

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By: Dr. Ann Agnes Mathew
21 April 2025

Rare Diseases in Children: Challenges, Advocacy and Hope

Most neurological diseases and conditions that affect small children and infants are rare. To give an example, children can have strokes, but they are not because of lifestyle choices, such as smoking or obesity as seen in the adult population.
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By: Dr. Ann Agnes Mathew
21 April 2025

Developmental Delays in Children: Early Signs and When to Seek Help

Children’s brain develops constantly, and the fastest pace of development is set between the first few years of life, more so during early infancy.
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By: Dr. Ann Agnes Mathew
21 April 2025

Epilepsy in Children Myths, Facts and Advances in Treatment

Epilepsy is a fairly common condition that is mostly treatable, affecting over 50 million people, the vast majority of whom are children. Hence obtaining a diagnosis as to what caused it and accessing the right treatment is of paramount importance as 70% are treatable.
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By: Dr. Ann Agnes Mathew
12 March 2025

Can brain surgery cure epilepsy

Epilepsy surgery or what is commonly called brain surgery, is one of the available modalities for treating epilepsy, where the area of the brain that causes seizures is removed.
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By: Dr. Ann Agnes Mathew
12 March 2025

Developmental Disorders: Should a child be held to a schedule

When one thinks about childhood, we often think of it as the golden age. While that is true, it is also the time of life when the human brain is most activeactive,
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By: Dr. Ann Agnes Mathew
11 March 2025

Why is it important to investigate Infantile or Epileptic Spasms (West syndrome)

Epileptic spasms during early childhood has devastating consequences. Its early identification through investigations such as EEG reduces neurodisability and changes the disease course due to early treatment.
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Reach Dr. Ann Agnes Mathew

Synapse Neuro Center

771, 10th Main Road, 34th Cross Rd, 4th Block, Jayanagar, Bengaluru, Karnataka 560011

Virgo Health Care

BRIGADE SIGNATURE TOWERS, Sannatammanahalli, Bengaluru, Karnataka 560049

SPARSH Hospital, Hennur

DivyaSree Avance, Hennur Bagalur Main Rd, Chikkanna Layout, HBR Layout, Geddalahalli, Bengaluru, Karnataka 560043